Cranial Hypoglossal Nerve Stimulation Publication – Categorized

Table of Contents

  1. Clinical Evidence of Safety and Efficacy (Inspire sponsored, Independent trials, case studies)
  2. Basic Science (mechanism of action, patient selection, surgical techniques, feasibility research)
  3. Economic Cost Effectiveness
  4. General Reviews

 
 
 

Clinical Evidence of Safety and Efficacy

Five groups of clinical data have been published including: A) Inspire STAR Phase III Clinical Trial, B) Inspire post-FDA approval clinical trials, C) Comparative studies to sleep surgeries, D) Independent clinical trials, E) Independent case studies of Inspire system

A) STAR Phase III Pivotal Trial: Primary safety and efficacy; Randomized controlled withdrawal study; Long-term (5-year) follow up

  1. Upper-airway stimulation for obstructive sleep apnea. Strollo PJ et al. N Engl J Med. 2014 Jan 9; 370(2):139-49.
  2. Hypoglossal-nerve stimulation for obstructive sleep apnea. Malhotra A. N Engl J Med. 2014 Jan 9; 370(2):170-1.
  3. Randomized controlled withdrawal study of upper airway stimulation on OSA: short- and long-term effect. Woodson BT et al. Otolaryngol Head Neck Surg. 2014 Nov; 151(5):880-7.
  4. Stimulation Therapy for Apnea Reduction (STAR) Trial Group. Upper Airway Stimulation for Obstructive Sleep Apnea: Durability of the Treatment Effect at 18 Months. Strollo PJ et al. Sleep. 2015 Oct 1;38(10):1593-8.
  5. Upper Airway Stimulation for Obstructive Sleep Apnea: Self-reported Outcomes at 24 Months. Soose RJ et al. J Clin Sleep Med. 2016 Jan;12(1):43-8.
  6. Three-Year Outcomes of Cranial Nerve Stimulation for Obstructive Sleep Apnea: The STAR Trial. Woodson BT et al. Otolaryngol Head Neck Surg. 2016, 154(1)181-8.
  7. Upper Airway Stimulation for Obstructive Sleep Apnea: Patient Reported Outcomes after 48 Months of Follow-up. Gillespie MB et al. Otolaryngol Head Neck Surg. 2017 Apr; 156(4): 765-771.
  8. Upper Airway Stimulation for Obstructive Sleep Apnea: 5-Year Outcomes. Woodson BT, Strohl KP, Soose RJ, Gillespie MB, et al. Otolaryngol Head Neck Surg. 2018 Jul;159(1):194-202.
  9. Hypoglossal Nerve Stimulation and Heart Rate Variability: Analysis of STAR Trial Responders. Dedhia RC, Shah AJ, Bliwise DL, Quyyumi AA, Strollo PJ, Li Q, Da Poian G, Clifford GD. Otolaryngol Head Neck Surg. 2019 Jan;160(1):165-171.

B) Post-Approval Clinical Trials of Inspire Therapy: ADHERE 2,500-patient registry & sub-analyses; Multi-center post market study 12-month and 6-month outcome; Pediatric patients with Down syndrome;

  1. Update on hypoglossal nerve stimulation in children with down syndrome and obstructive sleep apnea. Caloway CL, Diercks GR, Keamy D, de Guzman V, Soose R, Raol N, Shott SR, Ishman SL, Hartnick CJ. Laryngoscope. 2019 Jun 20. doi: 10.1002/lary.28138. [Epub ahead of print]
  2. Upper Airway Stimulation Response in Older Adults with Moderate to Severe Obstructive Sleep Apnea. Withrow K, Evans S, Harwick J, Kezirian E, Strollo P. Otolaryngol Head Neck Surg. 2019 May 14:194599819848709. doi: 10.1177/0194599819848709. [Epub ahead of print]
  3. Post-Approval Upper Airway Stimulation Predictors of Treatment Efficacy in the Adhere Registry. Heiser C, Steffen A, Boon M, et al, on behalf of the Adhere Registry Investigators. Eur Respir J. 2019 Jan 3;53(1)
  4. Upper Airway Stimulation for Obstructive Sleep Apnea: Results from the ADHERE Registry. Boon M, Huntley C, Steffen A, et al. Otolaryngol Head Neck Surg. 2018 Aug;159(2):379-385.
  5. Outcome after one year of upper airway stimulation for obstructive sleep apnea in a multicenter German post-market study. Steffen A, Sommer JU, Hofauer B, Maurer JT, Hasselbacher K, Heiser C. 2018 Feb;128(2):509-515.
  6. Patient-reported outcome: results of the multicenter German post-market study. Hasselbacher K, Hofauer B, Maurer JT, Heiser C, Steffen A, Sommer JU. Eur Arch Otorhinolaryngol. 2018 Jul;275(7):1913-1919.
  7. Outcomes of Upper Airway Stimulation for Obstructive Sleep Apnea in a Multi-center German Post-Market Study. Heiser et al.   Otolaryngology–Head and Neck Surgery. 2017 Feb; vol. 156, 2: pp. 378-384.
  8. Hypoglossal Nerve Stimulation in Adolescents with Down Syndrome and Obstructive Sleep Apnea. Diercks GR, Wentland C, Keamy D, Kinane TB, Skotko B, de Guzman V, Grealish E, Dobrowski J, Soose R, Hartnick CJ. JAMA Otolaryngol Head Neck Surg. 2018 Jan;144(1):37-42.

C) Comparison Clinical Studies to Sleep Surgery – not sponsored by Inspire Medical Systems, Inc.

  1. Uvulopalatopharyngoplasty vs CN XII stimulation for treatment of obstructive sleep apnea: A single institution experience. Shah J, Russell JO, Waters T, Kominsky AH, Trask D. Am J Otolaryngol. 2018 May – Jun;39(3):266-270.
  2. Comparing Upper Airway Stimulation to Expansion Sphincter Pharyngoplasty: A Single University Experience. Huntley C, Chou D, Doghramji K, et al. Annals of Otology, Rhinology & Laryngology. 2018 Jun;127(6):379-383.
  3. Transoral robotic surgery versus upper airway stimulation in select obstructive sleep apnea patients. Yu JL, Mahmoud A, Thaler ER. Laryngoscope. 2018 Sep 12. [Epub ahead of print]
  4. Comparing Upper Airway Stimulation to Transoral Robotic Base of Tongue Resection for Treatment of Obstructive Sleep Apnea. Huntley C, Topf MC, Christopher V, Doghramji K, Curry J, Boon M. Laryngoscope. 2019 Apr;129(4):1010-1013. doi: 10.1002/lary.27484. Epub 2018 Sep 12.

D) Independent Clinical Studies – not sponsored by Inspire Medical Systems, Inc.

  1. Previous Surgery and Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea. Kezirian EJ, Heiser C, Steffen A, Boon M, Hofauer B, Doghramji K, Maurer JT, Sommer JU, Soose RJ, Schwab R, Thaler E, Withrow K, Kominsky A, Larsen CG, Hsia J, Mehra R, Waters T, Strohl K. Otolaryngol Head Neck Surg. 2019 Jun 25. [Epub ahead of print]
  2. The Impact of Upper Airway Stimulation on Swallowing Function. Huntley C, Vasconcellos A, Mullen M, Chou DW, Geosits H, Doghramji K, Boon M. Ear Nose Throat J. 2019 May 29:145561319853519. doi: 10.1177/0145561319853519. [Epub ahead of print]
  3. Upper airway stimulation therapy and sleep architecture in patients with obstructive sleep apnea. Bohorquez D, Mahmoud AF, Yu JL, Thaler ER. Laryngoscope. 2019 May 7. doi: 10.1002/lary.28057. [Epub ahead of print]
  4. Increasing preoperative apnea severity improves upper airway stimulation response in OSA treatment. Evans SS, Richman J, Cho DY, Withrow K. Laryngoscope. 2019 Apr 30. doi: 10.1002/lary.28009. [Epub ahead of print]
  5. Outcomes of Hypoglossal Nerve Upper Airway Stimulation among Patients with Isolated Retropalatal Collapse. Mahmoud AF, Thaler ER. Otolaryngol Head Neck Surg. 2019 Mar 12:194599819835186. doi: 10.1177/0194599819835186. [Epub ahead of print]
  6. Upper airway stimulation in obstructive sleep apnea improves glucose metabolism and reduces hedonic drive for food. Steffen A, Chamorro R, Buyny L, Windjäger A, Wilms B, Hasselbacher K, Wollenberg B, Lehnert H, Schmid SM. J Sleep Res. 2018 Nov 19:e12794. [Epub ahead of print]
  7. Cardiovascular endpoints for obstructive sleep apnea with twelfth cranial nerve stimulation (CARDIOSA-12): Rationale and methods. Dedhia RC, Quyyumi AA, Park J, Shah AJ, Strollo PJ, Bliwise DL. Laryngoscope. 2018 Nov;128(11):2635-2643
  8. Hypoglossal Nerve Stimulator Implantation in a Non-Academic Setting: Two-Year Result. Weeks B, Bao G, Gilbert TM, Emdur L. Laryngoscope Investig Otolaryngol. 2018 Aug 9;3(4):315-318.
  9. Improved exposure of the hypoglossal branches during hypoglossal nerve stimulator implantation: clinical outcomes of twenty-patients at a single institution. Weidenbecher M, Tamaki A, Cabrera C, Strohl K. Clin Otolaryngol. 2019 Jan;44(1):72-76
  10. Upper airway stimulation in patients who have undergone unsuccessful prior palate surgery: an initial evaluation. Huntley C, Vasconcellos A, Doghramji K, Hofauer B, Heiser C, Boon M. Otolaryngol Head Neck Surg. 2018 Nov;159(5):938-940.
  11. Upper airway stimulation in patients with obstructive sleep apnea and an elevated body mass index: a multi-institutional review. Huntley C, Steffen A, Doghramji K, Hofauer B, Heiser C, Boon M. 2018 Oct;128(10):2425-2428.
  12. Selective upper airway stimulation in older patients. Zhu Z, Hofauer B, Wirth M, Hasselbacher K, Frohnhofen H, Heiser C, Steffen A. Respir Med. 2018 Jul;140:77-81.
  13. Upper airway stimulation for treatment of obstructive sleep apnea; an evaluation and comparison of outcomes at two academic centers. Huntley C, Kaffenberger T, Doghramji K, Soose R, Maurits B. J Clin Sleep Med.  2017;13(9): 1075-9.
  14. Upper airway stimulation for OSA: early adherence and outcome results of one center. Kent DT, Lee JJ, Strollo PJ Jr., Soose RJ. Otolaryngol Head Neck Surg. 2016 Jul;155(1)188-93.
  15. Single-Institution Experience and Learning Curve with Upper Airway Stimulation. Thaler ER, Schwab RJ. 126: S17–S19, 2016
  16. Selective upper airway stimulation for obstructive sleep apnea: a single center clinical experience. Heiser C, Knopf A, Bas M, Gahleitner C, Hofauer B. Eur Arch Otorhinolaryngol. 2017 Mar; 274(3):1727-34.
  17. Upper airway stimulation therapy and prior airway surgery for obstructive sleep apnea. Mahmoud AF, Thaler ER. Laryngoscope. 2018 Jun. 128:1486-9.
  18. Hypoglossal nerve stimulation on sleep and level of alertness in OSA: A preliminary study. Philip P, Heiser C, Bioulac S, Altena E, Penchet G, Cuny E, Hofauer B, Monteyrol PJ, Micoulaud-Franchi JA. Neurology. 2018 Aug 14;91(7):e615-e619

E) Independent Case Studies of the Inspire system

  1. Hypoglossal nerve stimulation in three adults with down syndrome and severe obstructive sleep apnea. Li C, Boon M, Ishman SL, Suurna MV. Laryngoscope. 2018 Dec 13. doi: 10.1002/lary.27723. [Epub ahead of print]
  2. Subpectoral implantation of the hypoglossal nerve stimulator: An effective technical modification. Deep NL, Hines JP, Parish JM, Hinni ML, Bansberg SF. 2018 . [Epub ahead of print]
  3. Successful upper airway stimulation therapy in an adult Down syndrome patient with severe obstructive sleep apnea. Van de Perck E, Beyers J, Dieltjens M, Op de Beeck S, Verbraecken J, Van de Heyning P, Boudewyns A, Vanderveken OM. Sleep Breath. 2018 Nov 14. [Epub ahead of print]
  4. Electroconvulsive therapy for depression in a patient with an Inspire hypoglossal nerve stimulator device for obstructive sleep apnea: A case report. Mingo K, Kominsky A. Am J Otolaryngol. 2018 Jul – Aug;39(4):462-463.
  5. Dysfunctional hypoglossal nerve stimulator after electrical cardioversion: A case series. Vasconcellos AP, Huntley CT, Schell AE, Soose RJ, Boon MS. Laryngoscope. 2018 Nov 15. [Epub ahead of print]
  6. Treatment of Comorbid Obstructive Sleep Apnea by Upper Airway Stimulation Results in Resolution of Debilitating Symptoms of Restless Legs Syndrome. Myc LA, Churnin IT, Jameson MJ, Davis EM. J Clin Sleep Med. 2018 Oct 15;14(10):1797-1800.
  7. Early feasibility of Hypoglossal Nerve Upper Airway Stimulator in Patients with Cardiac Implantable Electronic Devices and Continuous Positive Airway Pressure-Intolerant Severe Obstructive Sleep Apnea. Parikh V, Thaler E, Kato M, et al. Heart Rhythm. 2018 Aug;15(8):1165-1170.
  8. Effect of upper-airway stimulation on sleep architecture in patients with obstructive sleep apnea. Hofauer B, Philip P, Withth M, Knopf A, Heiser C. Sleep Breath. 2017 Dec;21(4):901-908.
  9. Adherence to Upper-Airway Stimulation in the Treatment of OSA. Hofauer B, Steffen A, Knopf A, Hasselbacher K, Heiser C. 2018 Feb;153(2):574-575.
  10. Hypoglossal nerve upper airway stimulator implantation after radiotherapy for head and neck malignancy. Zheng Z, Hu S, Chernobilsky B. Otolaryngol Head Neck Surg. 2017 July;157(1):160-161.
  11. Continuing the original Stanford Sleep Surgery protocol from upper airway reconstruction to upper airway stimulation: our first successful case. Liu SY, Riley RW. J Oral and Maxillofacial Surg. 2017 July; 75(7):1514-1518.
  12. Airway evaluation in response to hypoglossal nerve stimulation a case report. Elshebiny T, Venkat D, Strohl M, Strohl, K, Ponsky D, Palomo JM. J Dental Sleep Med. 2017;4(1)15-17.
  13. Implantation of a defibrillator in a patient with an upper airway stimulation device. Ong AA, O’Brien TX, Nguyen SA, Gillespie MB. Laryngoscope. 2016 Feb; 126(2):E86-9
  14. Hypoglossal nerve stimulator implantation in an adolescent with Down Syndrome and sleep apnea. Diercks GR, Keamy D, Kinane TB, Skotko B, Schwartz A, Grealish E, Dobrowski J, Soose R, Hartnick CJ. Pediatrics. 2016 May; 137(5).
  15. Hypoglossal nerve stimulation rescue surgery after multiple multilevel procedures for obstructive sleep apnea. Strohl M, Strohl KP, Palomo JM, Ponsky D. Am J Otolaryngol. 2016 37(1):51-3
  16. Severe obstructive sleep apnea treated with combination hypoglossal nerve stimulation and oral appliance therapy. Lee JJ, Sahu N, Rogers R, Soose RJ. J Dental Sleep Med. 2015; 2(4) 185-186.


 
 
 
 
 
 

Basic Science:

Following are manuscripts describing the Basic Science and Early Research of Hypoglossal Nerve Stimulation for the treatment of Obstructive Sleep Apnea for patient selection, mechanism of action, and surgical techniques.

Patient Selection: Drug-induced Sedated Endoscopy (DISE); predictor of therapy success

  1. Evaluation of drug-induced sleep endoscopy as a patient selection tool for implanted upper airway stimulation for obstructive sleep apnea. Vanderveken OM, Maurer JT, Hohenhorst W, Hamans E, Lin HS, Vroegop AV, Anders C, de Vries N, Van de Heyning PH. J Clin Sleep Med. 2013 May; 9(5):433-8.
  2. Application of drug-induced sleep endoscopy in patients treated with upper airway stimulation therapy. Ong AA, Ayers CM, Kezirian EJ, Woodson BT, de Vries N, Nguyen SA, Gillespie MB. World J Otorhionolaryngology-Head and Neck Surgery. 2017 Jun 9;3(2):92-96.
  3. Predictive success factors in selective upper airway stimulation. Heiser C, Hofauer B. ORL J Otorhin Relat Spec. 2017;79(1-2)
  4. Efficacy of upper airway stimulation on collapse patterns observed during drug-induced sedation endoscopy. Ong AA, Murphey AW, Nguyen SA, Soose RJ, Woodson BT, Vanderveken OM, de Vries N, Gillespie MB. Otolaryngol Head Neck Surg. 2016 May; 154(5):970-7
  5. Implanted upper airway stimulation device for obstructive sleep apnea. Van de Heyning PH et al. Laryngoscope. 2012 Jul; 122(7):1626-33.
  6. Patient selection for upper airway stimulation: is concentric collapse in sleep endoscopy predictable. Steffen A, Frenzel H, Wollenberg B, Konig IR. Sleep Breath. 2015;19:1373-1376
  7. Upper-Airway Stimulation Before, After, or Without Uvulopalatopharyngoplasty: A Two-Year Perspective. Steffen A, Abrams N, Suurna MV, Wollenberg B, Hasselbacher K. Laryngoscope. 2018 Sep 24. [Epub ahead of print]
  8. Evaluation of body position in upper airway stimulation for obstructive sleep apnea-is continuous voltage sufficient enough? Steffen A, Hartmann JT, König IR, Ravesloot MJL, Hofauer B, Heiser C. Sleep Breath. 2018 Dec;22(4):1207-1212.
  9. What makes the responder to upper airway stimulation in obstructive sleep apnea patients with positive airway pressure failure? Steffen, A. J Thorac Dis. 2018 Sep; 10(Suppl 26): S3131–S3134.

 

Mechanism of Action: Multi-level upper airway opening and effect of tongue motions

  1. Tongue motion variability with changes of upper airway stimulation electrode configuration and effects on treatment outcomes. Steffen A, Kilic A, Konlg IR, Suurna MV, Hofauer B, Heiser C. 2018 Aug;128(8):1970-1976.
  2. Effect of upper-airway stimulation for obstructive sleep apnoea on airway dimensions. Safiruddin F et al. Eur Respir J. 2015 Jan;45(1):129-38.
  3. Hyoid arch displacement with hypoglossal nerve stimulation. ElShebiny T, Venkat D, Strohl K, Hans MG, Alonso A, Palomo JM. Am J Respir Crit Care Med. 2017 Sept;196(6):790-792.
  4. Palatoglossus coupling in selective upper airway stimulation. Heiser C, Edenharter G, Bas, M, Wirth M, Hofauer B. Laryngoscope. 2017 Oct;127(10):E378-E383.
  5. Functional outcome of tongue motions with selective hypoglossal nerve stimulation in patients with obstructive sleep apnea. Heiser C, Maurer JT, Steffen A. Sleep Breath. 2016 May;20(2):553-60
  6. Sonographic evaluation of tongue motions during upper airway stimulation for obstructive sleep apnea – a pilot study. Hofauer B, Strohl K, Knopf A, Bas M, Wirth M, Stock K, Heiser C. Sleep Breath. 2017 Mar;21(1):101-107

 

Surgical Technique and Patient Management: The implant of the Inspire system and post-operative care

  1. Ultrasound Guidance for Implantation of Hypoglossal Nerve Stimulator in a Breast Implant Patient. Jonas R, Bradford-Bell E, Sebelik M, Dedhia RC. Laryngoscope. 2018 Nov;128(11):2651-2653. doi: 10.1002/lary.27511. Epub 2018 Sep 12.
  2. Development of a standardized evaluation of endobuccal adverse events induced by repeated tongue protrusion with both a dedicated questionnaire and an endobuccal examination. Catella C, Micoulaud-Franchi JA, Monteyrol PJ, Cuny E, Vanderveken OM, d’Incau E, Philip P. Eur Arch Otorhinolaryngol. 2019 Jan 28. doi: 10.1007/s00405-019-05298-8. [Epub ahead of print]
  3. Technical tips during implantation of selective upper airway stimulation. Heiser C, Thaler E, Soose R, Woodson BT, Boon M. Laryngoscope. 2018 Mar;128(3):756-762.
  4. Updates of operative techniques for upper airway stimulation. Heiser C, Thaler E, Boon M, Soose, RJ, Woodson BT. Laryngoscope. 2016 126: S12-S16.
  5. Acclimation setting with identical or similar sensation and function thresholds. Kezirian EJ. Laryngoscope. 2016, 126: S20-S21.
  6. Advanced titration to treat a floppy epiglottis in selective upper airway stimulation. Heiser C. Laryngoscope. 2016, 126: S22-S24.
  7. Nerve monitor-guided selective hypoglossal nerve stimulation in obstructive sleep apnea patients. Heiser C, Hofauer B, Lozier L, Woodson BT, Stark T. Laryngoscope. 2016 Dec;126(12):2852-8.
  8. Upper airway stimulation for obstructive sleep apnea: The surgical learning curve. Murphey AW, Baker AB, Soose RJ, Padyha TA, Nguyen SA, Xiao CC, Gillespie MB. Laryngoscope. 2016 Feb; 126(2):501-6
  9. Operative technique of upper airway stimulation: an implantable treatment of obstructive sleep apnea. Maurer JT, Van de Heyning PH, Lin HS, Baskin J, Anders C, Hohenhorst W, Woodson BT. Operative Technique in Otolaryngology – Head and Neck Surgery. 2012 Sep; 23(3): 227-233.

 

Basic Science and Early Research of hypoglossal nerve stimulation for the treatment of OSA

  1. Therapeutic electrical stimulation of the hypoglossal nerve in obstructive sleep apnea. Schwartz AR et al. Arch Otolaryngol Head Neck Surg. 2001 Oct; 127(10):1216-23.
  2. Electrical stimulation of the hypoglossal nerve: a potential therapy. Schwartz AR, Smith PL, Oliven A. J Appl Physiol. (1985). 2014 Feb 1;116(3):337-44.
  3. Hypoglossal nerve stimulation–optimizing its therapeutic potential in obstructive sleep apnea. Schwartz AR. J Neurol Sci. 2014 Nov 15;346(1-2):1-3.
  4. Treating obstructive sleep apnea with hypoglossal nerve stimulation. Oliven A. Curr Opin Pulm Med. 2011 Nov;17(6):419-24.
  5. Upper airway response to electrical stimulation of the genioglossus in obstructive sleep apnea. Oliven A et al. J Appl Physiol (1985). 2003 Nov;95(5):2023-9.
  6. Tongue neuromuscular and direct hypoglossal nerve stimulation for obstructive sleep apnea. Eisele DW et al. Otolaryngol Clin North Am. 2003 Jun;36(3):501-10. Review.
  7. The effect of neuromuscular stimulation of the genioglossus on the hypopharyngeal airway. Mann EA, Burnett T, Cornell S, Ludlow CL. Laryngoscope. 2002. Feb;112(2):351-6.
  8. Relief of upper airway obstruction with hypoglossal nerve stimulation in the canine. Goding GS Jr, Eisele DW, Testerman R, Smith PL, Roertgen K, Schwartz AR. Laryngoscope. 1998 Feb;108(2):162-9.
  9. Pharyngeal patency caused by stimulation of the hypoglossal nerve in anaesthesia-relaxed patients. Ilomäki J, Baer GA, Karhuketo T, Talonen P, Puhakka H. Acta Otolaryngol Suppl. 1997; 529:210-1.
  10. Direct hypoglossal nerve stimulation in obstructive sleep apnea. Eisele DW, Smith PL, Alam DS, Schwartz AR. Arch Otolaryngol Head Neck Surg. 1997 Jan;123(1):57-61.
  11. Electrical stimulation of upper airway musculature. Smith PL, Eisele DW, Podszus T, Penzel T, Grote L, Peter JH, Schwartz AR. Sleep. 1996 Dec;19(10 Suppl): S284-7.
  12. Neurostimulation for obstructive sleep apnea: investigations. Fairbanks DW, Fairbanks DN. Ear Nose Throat J. 1993 Jan;72(1):52-4, 57.


 
 
 
 
 
 

Economic Benefit of using Inspire therapy for the treatment of OSA

  1. Long-Term Cost-Effectiveness of Upper Airway Stimulation for the Treatment of Obstructive Sleep Apnea: A Model-Based Projection Based on the STAR Trial. Pietzsch JB et al. Sleep. 2015 May 1; 38(5):735-44.
  2. Clinical and Economic Benefits of Upper Airway Stimulation for Obstructive Sleep Apnea in a European Setting. Pietzsch JB, Richter AK, Randerath W, Steffen A, Liu S, Geisler BB, Wasem J, Biermann-Stallwitz J. Respiration. 2019 Mar 28:1-10. doi: 10.1159/000497101. [Epub ahead of print]


 
 
 
 
 
 

General Reviews:

Cranial Nerve (Hypoglossal) Stimulation for the treatment of OSA

  1. [Hypoglossal nerve stimulation for obstructive sleep apnoea; technique, indication and future prospects]. Vonk PE, Benoist LBL, Kasius KM, van Maanen JP, Ravesloot MJL, Reesink HJ, de Vries N. Ned Tijdschr Geneeskd. 2019 May 3;163. pii: D3286. Dutch.
  2. The terminal hypoglossal nerve and its anatomical variability. Heiser C, Knopf A, Hofauer B. HNO. 2019 Mar 14. doi: 10.1007/s00106-019-0632-8. [Epub ahead of print] Review. German.
  3. Sleep Surgery in the Era of Precision Medicine. Liu SY, Wayne Riley R, Pogrel A, Guilleminault C. Atlas Oral Maxillofac Surg Clin North Am. 2019 Mar;27(1):1-5. Review.
  4. Upper Airway (Hypoglossal Nerve) Stimulation for Treatment of Obstructive Sleep Apnea. Gupta RJ, Kademani D, Liu SY. Atlas Oral Maxillofac Surg Clin North Am. 2019 Mar;27(1):53-58. Review.
  5. Addressing the Tone and Synchrony Issue During Sleep: Pacing the Hypoglossal Nerve. Heiser C, Hofauer B. Sleep Med Clin. 2019 Mar;14(1):91-97. doi: 10.1016/j.jsmc.2018.10.010. Epub 2018 Dec 3.
  6. The Role of the Revised Stanford Protocol in Today’s Precision Medicine. Liu SY, Awad M, Riley R, Capasso R. Sleep Med Clin. 2019 Mar;14(1):99-107. doi: 10.1016/j.jsmc.2018.10.013.
  7. Thirty-five alternatives to positive airway pressure therapy for obstructive sleep apnea: an overview of meta-analyses. Camacho M, Chang ET, Neighbors CLP, Noller MW, Mack D, Capasso R, Kushida CA. Expert Rev Respir Med. 2018 Nov;12(11):919-929. doi: 10.1080/17476348.2018.1522253. Epub 2018 Oct 3.
  8. [Sleep apnea : diagnostic and therapeutic modalities in case of failure of the CPAP]. Geering S, Broome M, Heinzer R, Lambercy K. Rev Med Suisse. 2018 Oct 3;14(621):1751-1754. French.
  9. The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta-analysis. Kompelli AR, Ni JS, Nguyen SA, Lentsch EJ, Neskey DM, Meyer TA. World J Otorhinolaryngol Head Neck Surg. 2018 Sep 25;5(1):41-48. Review.
  10. Novel Therapies for Sleep Apnea-The Implants Have Arrived! Valladares EM, Hammond TC. Neurodiagn J. 2018;58(2):116-125.
  11. Treat OSA: current and emerging therapies beyond CPAP. Lorenzi-Filho G, Almeida FR, Strollo PJ. Respirology. 2017 Nov;22(8):1500-1507.
  12. Hypoglossal nerve stimulation for treatment of obstructive sleep apnea (OSA): a primer for oral and maxillofacial surgeons. Hong SO, Chen YF, Jung J, Kwon YD, Liu SYC. Maxillofac Plast Reconstr Surg. 2017 Sep 25;39(1):27. doi: 10.1186/s40902-017-0126-0. eCollection. 2017 Dec. Review
  13. Development of a clinical pathway and technical aspects of upper airway stimulation therapy for obstructive sleep apnea. Vanderveken OM, Beyers J, Op de Beeck S, Dieltjens M, Willemen M, Verbraecken JA, De Backer WA, Van de Heyning PH. Front Neurosci. 2017 Sep 21;11:523. doi: 10.3389/fnins.2017.00523. eCollection. 2017. Review
  14. Innovative Surgery for Obstructive Sleep Apnea: Nerve Stimulator. Sommer JU, Hörmann K. Adv Otorhinolaryngol. 2017; 80:116-124.
  15. Predictive success factors in selective upper airway stimulation. Heiser C, Hofauer B. ORL J Otorhin Relat Spec. 2017;79(1-2)
  16. Hypoglossal nerve stimulation for obstructive sleep apnea: a review of the literature. Wray CM, Thaler ER. World J Otorhionolaryngology-Head and Nech Surgery. 2016 Dec 22;2(4):230-233
  17. Upper airway stimulation therapy. Green KK, Woodson BT. Otolaryngol Clin North Am. 2016 Dec;49(6):1425-31.
  18. Origins of and implementation concepts for upper airway stimulation for obstructive sleep apnea. Strohl KP, Baskin J, Lance C, Ponsky D, Weidenbecher M, Strohl M, Yamauchi M. Respiratory Investigation. 2016 Jul;54(4)241-9.
  19. The role of upper airway stimulation therapy in the multidisciplinary management approach of obstructive sleep apnea in the adult patient. Doghramji K, Boon M. Laryngoscope. 2016, 126: S9-S11.
  20. Upper Airway Stimulation for Obstructive Sleep Apnea: Past, Present, and Future. Dedhia RC, Strollo PJ, Soose RJ. Sleep. 2015 Jun 1;38(6):899-906.
  21. Hypoglossal nerve stimulation in the treatment of obstructive sleep apnea: A systematic review and meta-analysis. Certal VF et al. 2015 May; 125(5):1254-64.
  22. Electrical stimulation of the hypoglossal nerve in the treatment of obstructive sleep apnea. Kezirian EJ et al. Sleep Med Rev. 2010 Oct;14(5):299-305.